Reports and Recordings | Medicines Discovery Catapult

Webinar – Understanding the PK / PD Relationship

MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Understanding the pharmacokinetic-pharmacodynamic (PK-PD) relationship in preclinical models is crucial to predicting an efficacious dose regime in man. Preclinical PK-PD analysis investigates the dose-response relationship of exposure and biological effect. The […]

Webinar – Chemistry and Formulation

MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. The chemistry discipline is instrumental at all stages of drug discovery, from the creation of diverse or targeted libraries for screening, through design, synthesis, formulation and ultimately the scale up and […]

Webinar – Optimising the Compound

MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. For a molecule to be worthy of entering preclinical development it needs to have the desired biological activity, as well as DMPK properties and a safety profile appropriate for the targeted […]

Webinar – Structural Approaches for Drug Discovery

MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Structural biology is a vital tool in the drug discovery pipeline. Proteins are the targets for most marketed drugs, and so uncovering the molecular structure of the biological target to high […]

Data Access Quick Guides – Access to the NIH Database of Genotypes and Phenotypes (dbGaP)

We have produced a series of Data Access Guides for a number of the major UK data suppliers that summarise the data they contain and how you might access it as an SME. The US National Institute of Health’s (NIH) National Center for Biotechnology Information (NCBI) is responsible for creating automated systems for storing and […]

Webinar – Connecting the Data Wires

Now more than ever, the need for establishing connections and closer collaboration is a priority for many organisations. Practical steps in establishing the areas for focus and priority isn’t as straight forward as it should initially seem to be. There is often a disconnect between the requirements and the provider solutions meaning that solutions, or […]

Webinar – Hit Identification

MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. The identification of high quality leads is an important step in the discovery of a new drug, but in order to achieve a relevant starting point there are several factors to […]

Webinar – Identifying the Target

MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Lack of efficacy is one of the most important causes of failure in clinical trials. Therefore identifying the biological target for a drug discovery project is one of the most important […]

The Issue with Tissue

About 1 million patients have consented to their samples being used specifically in research studies. There are a further 3 to 5 million samples held in tissue banks in the UK, where patients have permitted their sample to be used in future studies. However, it has been estimated that only 15% of samples donated for research are ever used. […]

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