Use of microfluidics technology to model α-synuclein aggregation and seeding in Parkinson’s disease in vitro

Many neurodegenerative diseases are associated with the presence of misfolded, aggregating proteins within the brain, leading to cytotoxicity and cell death. The prion hypothesis states that these toxic species spread through the brain via anatomically connected regions, leading to widespread neurodegeneration. α-synuclein is a protein that is implicated in the pathogenesis of Parkinson’s disease, as […]