× Medicines Discovery Catapult

The role of Senior Scientist – Genome Engineering would suit a highly motivated self-starter who is passionate about the application of cell and molecular biology to medicines discovery. The successful candidate will bring a depth of expertise in genome engineering and will apply their skills to support collaborative projects in complex cell models, cellular target engagement, and target validation. In alignment with the Catapult’s strategic focus on human, disease-relevant cell models, they will be able to manipulate primary and iPS-derived cells to improve patient and disease relevance. They will also develop and optimise molecular strategies to introduce tags, reporters and point mutations to these cells.

The individual will work closely with colleagues in interdisciplinary project teams and the role will involve extensive collaboration with external partners, including drug discovery companies, academic institutes and technology providers. The opportunity to join a world class laboratory team in this high profile national organisation, and contribute your ideas, insights and creative science to collaborative projects across the UK, should provide a fantastic platform for career development.

Main duties and responsibilities

  • Apply genome engineering expertise to support the delivery of collaborative projects focussed on disease-relevant cell model development, cellular target engagement and target validation.
  • Develop molecular strategies to introduce epitope tags and fluorescent labels to endogenous target proteins; to introduce reporter constructs; to disrupt/knockout target genes and to introduce point mutations to target proteins.
  • Identify new technology partnerships and tools to enhance the Medicines Discovery Catapult’s portfolio of innovative solutions.
  • Apply and adapt existing and novel genome engineering technologies to manipulate target proteins in primary and iPS-derived cells.
  • Working with Medicines Discovery Catapult colleagues, characterise and exploit the resulting cell models, using advanced microscopy and other cell assay methods.
  • Deliver high quality data in a complex and time pressured research team environment.
  • Manage complex collaborative projects with external partners to completion.
  • Implement effective lab processes, experimental records, and safety.
  • Contribute scientific insight and innovative technical approaches for more successful drug discovery programmes.
  • Demonstrate effective communication and research collaboration skills, working with a wide range of colleagues in academic and commercial organisations.

Qualifications and Experience

  • The successful candidates will possess a PhD (or have similar experience) along with substantial relevant experience in the field of cell and molecular biology.
  • Proven, practical expertise in genome engineering, demonstrated by a strong track record of delivery and a strong publication record.
  • Broad knowledge of established and emerging innovative technologies in the field of genome engineering, supported by a strong network in the field.
  • Experience in handling and manipulating primary and iPS-derived cells is preferred.
  • In depth knowledge and practical experience of conventional cell and molecular biology techniques, including transfection, cell line generation, western blot and DNA isolation and sequencing.
  • Experience in the routine use of informatic software tools to support project workflows.
  • A practical experience of working with cellular assay technologies, including microscopy and fluorescence-based cell assays would be an advantage.
  • Experience of working in collaborative project teams, with both internal and external colleagues; experience of working in a medicine discovery setting would be an advantage.
  • Ability to work on multiple projects simultaneously in a highly collaborative and inter-disciplinary environment.
  • Ability to communicate effectively with both experts and non-experts in the field.