CF AMR Syndicate

Accelerating the discovery and translation of novel CF antimicrobials to the clinic

Medicines Discovery Catapult has joined forces with the Cystic Fibrosis Trust to form the CF AMR Syndicate.

The CF AMR Syndicate brings industry leaders and people affected by CF together with academics with expertise in CF and pulmonary infection.

The CF Syndicate in AMR is discussed in the Cystic Fibrosis Trust’s Research in focus: Antimicrobial resistance in cystic fibrosis report

Read more about how the partnership is attempting to get more antimicrobial drugs to people with cystic fibrosis faster by bringing together those with the condition and experts from academia and industry to identify and overcome barriers during the drug discovery and development process.

Read the report on the Cystic Fibrosis Trust website >

CF is a life-limiting disease affecting over 10,500 people in the UK. People with CF experience a build-up of thick sticky mucus in their lungs and other organs, which leads to the development of frequent and persistent infections. AMR is frequently seen in people with CF, who die from antibiotic failures. The discovery and development of new antimicrobials to treat infections associated with CF is, therefore, an urgent unmet need.

The collective, cross-sector expertise of the CF AMR Syndicate enables new efforts in the discovery of CF antimicrobials, to accelerate translation to the clinic and to ultimately bring better treatment options to people affected by CF, faster.

Since launching in September 2019, the CF AMR Syndicate has engaged with the UK CF infection research community in academia and industry to understand the challenges in the discovery and translation of novel antimicrobials to the clinic to treat infections associated with CF.

Key challenges

  • No agreed preclinical screening and testing pathways, and a lack of robust preclinical models of CF
  • Difficulty to access clinically relevant samples, which are essential for the screening and testing of new CF antimicrobials, before they can be tested in the clinic

To address these challenges, the CF AMR Syndicate will catalyse new research efforts and build capacity in the following areas:

  1. Streamline and enable access to clinically relevant samples for the preclinical screening and testing of CF antimicrobials
  2. Map and validate the preclinical screening and testing pathways to provide faster routes to bring CF antimicrobials to the clinic
  3. Develop guidance for industry on the key characteristics and requirements that CF antimicrobials should meet in order to address the needs and priorities of people with CF, through the development of Target Product Profiles.

Find out more

If you’d like to find out more about the CF AMR Syndicate, or if you have expertise or capabilities to support our ongoing work, please fill in the contact form to get in touch.

If you are someone that is affected by CF and are looking for more information about CF, please refer to the Cystic Fibrosis Trust website.