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Candidate Selection









Advancing the right molecules through Candidate Selection

Candidate Selection is the moment when promising drug molecules are evaluated and prioritised for progression into preclinical and first-in-human studies, this is a critical decision point in the drug discovery process.

Selecting the most viable drug candidate requires a clear understanding of pharmacology, safety, exposure, and manufacturability.

We help you to identify, assess, and select the drug candidates with the best chance of clinical success.

Our integrated candidate selection approach combines biological insight, advanced analytics, and real-world experience to support your programme with the evidence needed to move forward confidently.


A scientist transferring samples in a well-plate with a multichannel pipette in a laboratory.

























Our approach to Candidate Selection

Our candidate selection approach is flexible and data-driven, designed to support early, informed decision-making and reduce risk in the drug discovery process.

We combine deep therapeutic expertise with advanced platforms to address the most pressing questions in candidate selection. Our capabilities span in vivo imaging, ex vivo tissue analysis, biomarker assay development, and mechanism of action studies, delivered by expert teams with extensive preclinical and translational science experience.

Our in vivo imaging platform enables detailed assessment of drug candidates across a range of disease models, with strength in oncology and PET imaging. This is complemented by comprehensive ex vivo tissue analysis, which supports spatial and molecular profiling at the cellular level.

We also help partners develop robust biomarker strategies and assays that are GCLP-compliant and ready for use on clinical trial samples.

By generating high-quality data on pharmacodynamics and biological activity, we provide a clearer understanding of mechanism of action, ensuring strong alignment between candidate molecules and disease biology.




How we can support your drug discovery project

We offer end-to-end support to help you identify and advance the most promising drug candidates with confidence:

  • Delivering key data to enable selection of candidates most likely to succeed in clinical trials.
  • In vivo biodistribution and efficacy in a range of disease models, using an extensive preclinical imaging suite that includes radiochemistry and PET imaging, gamma counting, fluorescence/luminescence imaging and ultrasound.
  • Ex vivo tissue analysis with IHC, spatial transcriptomics, microscopy and mass spectrometry.
  • Immune phenotyping in blood and tissue via flow cytometry and Luminex.
  • Biomarker platform for liquid sample (plasma and other) and tissue analysis, including development of assays to GCLP standards for use in clinical studies.
  • Mechanism of action studies to address key questions.









See how we have helped innovators


CPSA is an ingenious extension of the target engagement toolbox. It is easier to upscale and control in high throughput screening applications than currently available methods. With exemplary support from MDC we have smoothly incorporated it into our Drug Discovery pipeline.

Selvita

MDC’s R&D consulting has been transformative, refining our HT8457S strategy with scientific rigour, identifying and mitigating risks, and strengthening our business model, significantly enhancing Haiku’s credibility.

Haiku Therapeutics

The partnership with MDC has allowed us to secure multiple Innovate UK grants and utilise capabilities such as state-of-the-art PET, which aren’t available elsewhere.

Alchemab Therapeutics

For the first time, we have been able to generate a map of lung fibrosis in 3D at the tissue scale. Collaborating with MDC has been key to its success. Their expertise has supported the successful integration of state-of-the-art technologies, establishing a valuable new resource for the lung fibrosis community.

University of Southampton

Working with MDC allowed us to visualise drug distribution in the brain with a level of clarity we hadn’t achieved before. Their expertise in DESI-MS and willingness to design a project that met our demands provided powerful insights into diffusion patterns, giving us confidence in our compound’s delivery.

TargTex

We worked with the Mass Spectrometry team at MDC to help set up and run a complex biochemical assay. The project was technically demanding, but the deep expertise, knowledge and collaborative approach allowed the team to troubleshoot the many challenges and successfully deliver a viable approach.

Oppilotech

The team at MDC shares our passion for bringing forward innovative medicines, pioneering new technologies, and operating with data-driven flexibility. They have been integral to our project success and possess unique capabilities to support later-stage candidate selection. A truly valued collaborator and dependable partner.

Artbio

Elasmogen was impressed by the quality and rapid delivery timelines for our radiopharmaceutical dosimetry data. There was good interactivity in this project, and we are happy to recommend this service.

Elasmogen

Our collaboration with Medicines Discovery Catapult will not only enable us to engage with the wider scientific community but will also allow us to unlock the potential of Acoustic Mass Spectrometry within drug discovery.

Innovative Medicines and Early Development (IMED) Biotech Unit, AstraZeneca

It’s been absolutely amazing working with MDC and the team.

LUNAC Therapeutics

MDC supported us in developing a therapeutic for Huntington’s Disease through antibody characterisation, iPSC model development, biodistribution studies, imaging and neurodegenerative expertise.

Alchemab Therapeutics

We worked together with MDC on a very challenging and demanding project. The MDC team’s expertise in MSI, commitment and flexibility were key to a successful collaboration and reaching our objectives.

TargTex

MDC are as involved in our project as the founding team, going above and beyond what I expected. I recommend them to new ventures starting out; even if you don’t know exactly what you need, the team can work with you to achieve some phenomenal results.

KLAS Therapeutics

Working with MDC has provided expertise and intellectual input. It has also enabled access to a wider network of companies providing specialist services.

N4 Pharma

By tapping into MDC’s unique drug development expertise and facilities, we are confident we will accelerate the preclinical development of our drug delivery system and its commercialisation.

Sixfold Bioscience

It has been a pleasure working with MDC as their scientists are pleasant and have a broad range of talents.
Importantly for projects like ours, they openly and professionally exchange ideas with SMi’s scientific team and keep us abreast of their research developments.

SMi Systems

It has been great to access the Artificial Intelligence expertise at Medicines Discovery Catapult.
The team has taken an innovative approach that adds value to our product and will benefit our customers.

BioAscent

As an SME, working with MDC allows us access to scientific know-how and in vivo imaging techniques that would be impossible through any other route. The closeness, timeliness and flexibility of the collaboration significantly accelerated our ability to develop the product.

Xerion Healthcare

We have collaborated with MDC for three years, and it continues to provide valuable and high-quality data on our molecules. MDC’s input has directly impacted operational and strategic decisions for our projects and allowed us to move forward with our clinical studies.

Revolo Biotherapeutics

For early-stage SMEs in this space, I thoroughly recommend engaging with MDC, who have the end-to-end knowledge in complex medicines, can support your in-house team and provide access to key equipment that start-ups may not have.

pHion Therapeutics








Candidate Selection is where scientific ambition meets translational reality. We help you to make confident, informed decisions, tailored to real clinical need and grounded in robust data.”

Martin Main, Chief Scientific Officer

a photo of MDC Chief Scientific Officer Dr Martin Main






Need guidance for identifying and selecting drug candidates?

We can help you identify and select the best drug candidate for translation into the clinic and answer your most important questions.

Fill in the form today and speak to us to see how we can help advance your drug discovery project.