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How to study the endosomal escape of RNA therapeutics
MDC are attending Nordic Life Science Days in Stockholm, Sweden, from the 8-9 September 2026
MDC and NPIP are exhibiting at EANM 2026 in Vienna, Austria.
MDC are exhibiting at ELRIG Drug Discovery 2026, at Excel, London.
Come and visit MDC at our booth at the event – more information to follow.
Xenium at MDC Case Study: Hypoxia in Head and Neck Cancer
The centre will provide integrated expertise and evidence generation to help innovators accelerate the development of next-generation RNA medicines.
From mitochondrial networks that silently rebalance fusion and fission, to chromosomes that only reveal their fate in the minutes after division, live-cell imaging uncovers dynamics that static snapshots miss entirely. We explore three examples, including how tracking RNA therapeutic vehicles as they transit and escape endosomal compartments in real time resolves ambiguity that even super-resolution imaging of fixed cells can’t overcome.
By looking beyond the diffraction limit, we have established a method to quantitatively distinguish low-grade breast cancers that appear identical by traditional means. Ultimately, this nanoscale insight could expand access to novel HER2-targeted therapies by reliably identifying low expressing cohorts that would benefit from intervention.
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