Opening new avenues for RNA therapeutics through a preclinical screening and optimisation platform. In this blog, Lead Scientist Dr Phil Auckland describes how applying this platform to a library of 4,500 lipid nanoparticle (LNP) formulations enabled the identification of novel candidates with desirable mechanistic properties and in vivo functionality. Furthermore, we show that integrating multiple in vitro readouts can enhance prediction and thereby improve translation.
Preclinical data are essential for decision‑making in radiopharmaceutical development, and all stakeholders require a robust evidence base. However, each stakeholder brings a slightly different lens to both designing studies and interpreting the resulting evidence.
This is the first in a series of radiopharmaceutical blogs from Dr Juliana Maynard. Juliana is an expert imaging scientist with over 20 years’ experience in nuclear medicine and translational imaging.
In this blog, Dr Phil Auckland details how MDC has established a reproducible CRISPR-Cas9 pipeline and generated new tools to better inform nanotherapeutic design
Nanotherapeutics often fail because of Endosomal entrapment. In this blog by Dr Phil Auckland, we explore how MDC are using real-time imaging to reveal why.
Accelerating analgesic development through human-specific in vitro systems
Preclinical to clinical, building a translational link between in vitro and in vivo models of neuroinflammation for drug discovery.
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