× Medicines Discovery Catapult

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources
Read the full article at Drug Discovery Today >

Discovery

Information-rich high-throughput cellular assays using acoustic mist ionisation mass spectrometry
Read the full article at Analyst >

Coupling 193 nm Ultraviolet Photodissociation and Ion Mobility for Sequence Characterization of Conformationally-Selected Peptides
Read the full article in the Journal of the American Society for Mass Spectrometry >

Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption
Read the full article at Bioengineering >

Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues
Read the full article at Theranostics >

Investigating sex determination through MALDI MS analysis of peptides and proteins in natural fingermarks through comprehensive statistical modelling
Read the full article in Forensic Chemistry >

Coupling Droplet Microfluidics with Mass Spectrometry for Ultrahigh-Throughput Analysis of Complex Mixtures up to and above 30 Hz
Read the full article in Analytical Chemistry >

Part 2: SLAS Community Engages in the COVID-19 Fight
Read the full article in SLAS >

What makes a drug discovery consortium successful?
Read the full article in Nature Reviews Drug Discovery >

Quantification of protein glycation using vibrational spectroscopy
Read the full article at the Royal Society of Chemistry >

A practical guide to secondary pharmacology in drug discovery
Read the full article in the Journal of Pharmacological and Toxicological Methods >

Using Collision Cross Section Distributions to Assess the Distribution of Collision Cross Section Values
Read the full article in Analytical Chemistry >

High-resolution 3D visualization of nanomedicine distribution in tumors
Read the full article at Theranostics >

Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA
Read the full article at Nature Scientific Reports >

Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative
Read the full article in the British Journal of Pharmacology >

Organ-on-a-chip technology: turning its potential for clinical benefit into reality
Read the full article at Drug Discovery Today >

Acoustic mist ionization platform for direct and contactless ultrahigh-throughput MS analysis of liquid samples
Read the full article at Analytical Chemistry >

Generating Kidney from Stem Cells
Read the full article in the Annual Review of Physiology >

Evaluation of variability in human kidney organoids
Read the full article at Nature Methods >

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1
Read the full article at Sage Journals >

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
Read the full article at Nature Communications >

Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data
Read the full article at RMD Open >

The future R&D landscape in non-alcoholic steatohepatitis (NASH)
Read the article at Drug Discovery Today >

Rapid translation of novel nephrogenetic aetiologies from first report to accredited diagnostic outcome
Read the article at the Australian and New Zealand Society of Nephrology >

Monoclonal antibody targeting of fibroblast growth factor receptor 1c causes cardiac valvulopathy in rats
Read the article at Toxicology and Applied Pharmacology >

Combined inhibition of PI3Kβ and mTOR inhibits growth of PTEN null tumours
Read the article at Molecular Cancer Therapeutics >

Bubbling up: Introducing a new drug delivery method, microbubbles
Read the article at European Pharmaceutical Manufacturer >

Circulating biomarkers and resistance to endocrine therapy in metastatic breast cancers: correlative results from AZD9496 oral SERD Phase I trial
Read the article at Clinical Cancer Research >

2′-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells
Read the paper at Toxological Sciences >

Nucleic acid extraction from formalin-fixed paraffin-embedded cancer cell line samples: a tradeoff between quantity and quality?
Read the article at BMC Clinical Pathology >

Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute’s Cellular Molecular Pathology (CM-Path) initiative
Read the article at the Journal of Clinical Pathology >

Informatics

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease
Read the full article in the Cochrane Library >

Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates
Read the full article in Nucleic Acids Research >

Artificial intelligence, drug repurposing and peer review
Read the article at Nature Biotechnology >

A strategy for large-scale comparison of evolutionary- and reaction-based classifications of enzyme function
Read the article at Database >

A global analysis of function and conservation of catalytic residues in enzymes
Read the article at the Journal of Biological Chemistry >

Improving the odds of drug development success through human genomics: modelling study
Read the article at Scientific Reports >

Setting Our Sights on Infectious Diseases
Read the article at ACS Infectious Diseases >

Unexplored therapeutic opportunities in the human genome
Read the article at Nature Reviews Drug Discovery >

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Read the article at Cell Chemical Biology >

Chapter One – Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a “Plug and Play” Domain
Read the article at Methods in Enzymology >

Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites
Read the article in Nucleic Acids Research >

Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling
Read the article at the Journal of Chemical Information and Modeling >

A global view of structure–function relationships in the tautomerase superfamily
Read the article in the Journal of Biological Chemistry >

The ELF Honest Data Broker: informatics enabling public–private collaboration in a precompetitive arena
Read the article at Drug Discovery Today >

The importance of triaging in determining the quality of output from high-throughput screening
Read the article at Future Medicinal Chemistry >

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach
Read the article at Frontiers in Pharmacology >

Structural and Functional View of Polypharmacology
Read the article at Nature Scientific Reports >

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