× Medicines Discovery Catapult

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources
Read the full article at Drug Discovery Today >

Discovery Science & Technology

Organ-on-a-chip technology: turning its potential for clinical benefit into reality
Read the full article at Drug Discovery Today >

Acoustic mist ionization platform for direct and contactless ultrahigh-throughput MS analysis of liquid samples
Read the full article at Analytical Chemistry >

Generating Kidney from Stem Cells
Read the full article in the Annual Review of Physiology >

Evaluation of variability in human kidney organoids
Read the full article at Nature Methods >

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1
Read the full article at Sage Journals >

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
Read the full article at Nature Communications >

Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data
Read the full article at RMD Open >

The future R&D landscape in non-alcoholic steatohepatitis (NASH)
Read the article at Drug Discovery Today >

Rapid translation of novel nephrogenetic aetiologies from first report to accredited diagnostic outcome
Read the article at the Australian and New Zealand Society of Nephrology >

Monoclonal antibody targeting of fibroblast growth factor receptor 1c causes cardiac valvulopathy in rats
Read the article at Toxicology and Applied Pharmacology >

Combined inhibition of PI3Kβ and mTOR inhibits growth of PTEN null tumours
Read the article at Molecular Cancer Therapeutics >

Bubbling up: Introducing a new drug delivery method, microbubbles
Read the article at European Pharmaceutical Manufacturer >

Circulating biomarkers and resistance to endocrine therapy in metastatic breast cancers: correlative results from AZD9496 oral SERD Phase I trial
Read the article at Clinical Cancer Research >

2′-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells
Read the paper at Toxological Sciences >

Nucleic acid extraction from formalin-fixed paraffin-embedded cancer cell line samples: a tradeoff between quantity and quality?
Read the article at BMC Clinical Pathology >


Unexplored therapeutic opportunities in the human genome
Read the article at Nature Reviews Drug Discovery >

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Read the article at Cell Chemical Biology >

Chapter One – Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a “Plug and Play” Domain
Read the article at Methods in Enzymology >

Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites
Read the article in Nucleic Acids Research >

Identification of Allosteric Modulators of Metabotropic Glutamate 7 Receptor Using Proteochemometric Modeling
Read the article at the Journal of Chemical Information and Modeling >

A global view of structure–function relationships in the tautomerase superfamily
Read the article in the Journal of Biological Chemistry >

The ELF Honest Data Broker: informatics enabling public–private collaboration in a precompetitive arena
Read the article at Drug Discovery Today >

The importance of triaging in determining the quality of output from high-throughput screening
Read the article at Future Medicinal Chemistry >

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach
Read the article at Frontiers in Pharmacology >

Structural and Functional View of Polypharmacology
Read the article at Nature Scientific Reports >

Samples & Data

Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute’s Cellular Molecular Pathology (CM-Path) initiative
Read the article at the Journal of Clinical Pathology >

Closeup of the edge of open book pages