A human iPSC platform for studying pathogenic protein aggregation in neurodegeneration

 Introduction 

Protein misfolding, phosphorylation, and aggregation are central features of many neurodegenerative diseases 

These pathogenic proteins can seed further misfolding and propagate pathology across anatomically connected brain regions 

These processes contribute to cellular dysfunction and death, and are increasingly being targeted by novel therapeutics in the drug discovery landscape 

MDC has developed human in vitro systems to study the pathology of α-synuclein and tau in iPSC-derived cortical neurons in 96- and 384-well format using high content imaging assays and analysis pipelines