Large molecules, also known as biologics or biopharmaceuticals, represent one of the most transformative areas in modern medicine.
These complex, high-molecular-weight therapeutics, including monoclonal antibodies, therapeutic proteins and other biologically active macromolecules are typically manufactured or derived from biological sources.
They offer high-affinity and specificity for the target protein and can be designed to bind to multiple target proteins simultaneously.
They have a distinct pharmacokinetic and pharmacodynamic profile to small molecules and have had an enormous therapeutic impact in areas such as oncology, immunology and respiratory disorders.
We offer end-to-end support for large molecule drug discovery, from early discovery through to IND-enabled studies.
Whether you are working with antibodies, RNA-based therapeutics or other biologics, our integrated platforms are built to address the specific challenges of complex molecules, such as delivery, stability, and mechanism of action.
We work collaboratively with partners to evaluate lead and candidate biologics using physiologically relevant models and advanced analytical techniques, including high-resolution imaging, flow cytometry, and multi-omics profiling.
Our preclinical and ex vivo assays are designed to support pharmacological assessment, biodistribution, and pharmacodynamic response.
Our Translational Medicine team supports your large molecule pipeline with bespoke biomarker strategies, while our Drug Discovery Consultancy team provides insight into regulatory expectations and helps define a clear route from discovery to clinic.
We bring the right skills, expertise and discovery platforms to support your large molecule drug discovery project through the following phases:
“Large molecule therapies are a cornerstone of modern medicine, but turning great ideas into robust, scalable treatments still takes the right expertise. At MDC, we help biologics innovators make confident decisions and rapidly move from discovery to clinic.”
Dr Martin Main, Chief Scientific Officer
We can help you to validate, optimise and progress your large molecules, accelerating your discovery process and answering your most important questions.
Fill in the form today and speak to us to see how we can help advance your drug discovery project.