Small molecules remain a cornerstone of the drug discovery process, delivering therapeutic impact across nearly every disease area.
From enzyme inhibitors to receptor modulators, small molecules continue to enable life-changing medicines and expand our understanding of disease biology through use as chemical probes.
While newer modalities like biologics and RNA therapeutics have broadened the drug discovery toolbox, small molecules remain uniquely versatile. They can be delivered orally or through other routes and manufactured at scale in a cost-effective manner.
They are capable of subtly modulating target function and penetrating cells, making them ideal for targeting intracellular proteins and signalling pathways.
We offer comprehensive support to the small molecule drug discovery value chain. From Lead Generation, through Lead Optimisation, to Candidate Nomination and IND-enabling studies, our integrated capabilities are designed to reduce risk, improve quality, and accelerate progression into the clinic.
We work collaboratively with partners to evaluate their hit, lead and candidate molecules in a suite of translatable biological assays using state-of-the art technology platforms and industry-standard workflows.
Our Translational Medicine team can develop and implement a biomarker strategy to support progression through the clinic, and our R&D Consultancy team has the expertise required to shape the most efficient path for your small molecule programme.
We bring the right skills, expertise and discovery platforms to support your small molecule drug discovery project through the following phases:
“The importance of small molecule therapeutics cannot be understated, and drug discovery in this area continues to unlock major breakthroughs in medicine. By combining deep expertise with modern tools, we help innovators design and deliver high-quality chemical entities with the greatest chance of clinical success.”
Dr Martin Main, Chief Scientific Officer
We can help you to validate, optimise and progress your small molecules, accelerating your discovery process and answering your most important questions.
Fill in the form today and speak to us to see how we can help advance your drug discovery project.