Understanding and modulating the immune response is a fast-evolving area for therapeutic development, with a focus on the key role immunology plays in many diseases.
Immune dysfunction underpins a wide spectrum of conditions, from autoimmune disorders and allergies to neuroinflammatory diseases, metabolic disease, infections and cancer.
Despite it’s central role in pathology, many patients still face limited treatment options, particularly in complex or chronic conditions where the immune system is dysregulated, as manipulation of the tightly controlled immune system, can have adverse effects in the patient.
There remains a pressing need for targeted, effective, and personalised immunotherapies that can deliver better outcomes with fewer side effects.
We help innovators overcome the scientific and translational barriers that have historically slowed progress in this critical area.
We provide end-to-end support for immune-targeted drug discovery, combining immunology expertise with translational biology platforms. Our team develops and applies primary immune cell assays in multi-cellular models, for targeted mechanistic and phenotypic studies, depending on the research question.
We can evaluate therapeutics in antigen-specific assays and evaluate drug efficacy in patient-relevant ex vivo assays.
Using technologies like flow cytometry, Luminex, and high-content microscopy, we analyse cell phenotype within mixed cell populations, evaluate functional response and measure translational biomarkers in preclinical and patient-derived samples.
This translational approach is integrated with ex vivo tissue analysis and access to disease-relevant donors, ensuring data-rich, clinically relevant insights at every stage of development.
Develop disease-relevant in vitro models
We can develop complex immune assays to understand cellular response to therapeutics. Our assays use primary cells from human blood or preclinical models to model disease biology, and test immunomodulatory therapies in a physiologically relevant way.
Interrogate immune responses and mechanisms of action
Using flow cytometry, multiplex protein analysis, transcriptomic analysis and imaging, we help characterise how your therapeutic interacts with and modifies immune function.
Evaluate biomarkers and clinical translatability
Our multi-omic platforms, including single cell, spatial tissue, and liquid sample analysis can identify molecular signatures of disease and drug response, helping build evidence to support for clinical progression.
Access to disease-relevant samples and donors
We understand the importance of translational preclinical research and ensure the cells and samples we use have clinical relevance, by working with human cells and tissue , and where relevant, patient material.
“We are interested in understanding your translational challenges and can help you navigate the complexity of immunology. Using our technology platforms with integrated research and analysis we provide key data to drive forward the next generation of immune-targeted therapies”
Dr Emily Offer, Head of In vitro Biology
Our team of experienced immunologists is here to help you understand your drug discovery project and tailor solutions to your specific research goals.
Fill in the form today and speak to us to see how we can help advance your drug discovery project.