Introduction
Protein misfolding, phosphorylation, and aggregation are central features of many neurodegenerative diseases
These pathogenic proteins can seed further misfolding and propagate pathology across anatomically connected brain regions
These processes contribute to cellular dysfunction and death, and are increasingly being targeted by novel therapeutics in the drug discovery landscape
MDC has developed human in vitro systems to study the pathology of α-synuclein and tau in iPSC-derived cortical neurons in 96- and 384-well format using high content imaging assays and analysis pipelines
Poster
View the poster here
