Home » Publications » Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates
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Dr Eve Corrie, Dr Rebecca ...
Dr Eve Corrie, Dr Rebecca Kelly, Dr Matthieu Trigano, and Dr Emma V. Jones
Advanced Microscopy Tools for Drug ...
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Expert-Led Consensus to Sha...
Medicines Discovery Catapult, MND Association and My Name’5 Doddie Foundation have partnered to generate new…
Development of Microscopy Tools to ...
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Imaging informatics at Medicines Di...
Nina Vyas, Adam Callan-Sidat, Hervé Barjat
Spatially Resolved Whole Transcript...
Robert Pedley, Michael Eyres, Joesph Bell, Nina Vyas, Herve Barjat1, Donna Davies, Mark Jones, Gayle Marshall, Emily Offer
Identification and Profiling of Bio...
Kerry Shea, Regine Anderson, Michael Eyres, Bruno Bellina, Tara Bowen, Maike Langini, Andrzej Rutkowski, Philippa Hart, Irma Berruta Razo, Lucy Frost, Gayle Marshall
Visualising the biodistribution of ...
Irma Berrueta Razo, Tiffany Allen and Philippa Hart
Nature Feature Article Dece...
Feature article in Nature: Collaboration is reshaping the future of UK drug discovery. Medicines Discovery…
Rebecca Kelly, Eve Corrie, ...
Multimodal Advanced Microscopy to Study Drug Responses in Complex Cell Models More translational models are…
Eve Corrie, Isabel Peset-Ma...
Methods to Examine Neuronal Morphology and Function in Human iPSC-derived Disease Models The ability to…
Eleanor Platt, Lucy Frost, ...
Understanding the Senolytic and Senomorphic Effects of Zoledronate in an Ageing Mouse Model Bisphosphonates (BPs)…
Irma Berrueta Razo, Ping Yi...
Investigation of Lipid Biomarkers in Amyotrophic Lateral Sclerosis Using Mass Spectrometry Imaging The application of…
Emma V. Jones, Lorna M. Fit...
Drug Discovery Tools to Examine Neuroinflammation Signalling in Human iPSC-Derived Microglia Huge challenges exist in…
Michael Eyres, Phillipa Har...
Whole Transcriptome Digital Spatial Profiling of Pain-Induced DRGs Tissues are not homogenous but are made…
Kepa Burusco-Goni, Mouhamad...
A Journey from Protein to Compound: Virtual Screening at MDC: Lately, there has been an…
Aadarash Zia, Nisha Ponnapp...
Efficient Intracellular Delivery of Nucleic Acids by NUVEC® Silica Nanoparticles: In recent years, there has…
Spatially Resolved Deconvolution of...
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Constance Takawira, Paula S...
This poster presents our flagship programme in infectious disease – The Cystic Fibrosis Antimicrobial Resistance…
Gender Pay Gap Report
Medicines Discovery Catapult is committed to equality of opportunity. It has recently formalised its long-held commitment…
Advanced Molecular Imaging for the ...
Our industry experts, Dr Paul Sharp (Senior Scientist) and Dr Martin Main (Head of Discovery)…
Drug Discovery Today
Hearing loss is a serious condition affecting more than 1.5 billion people globally. Many…
IMI European Lead Factory – d...
Our CSO, Prof. Peter Simpson has contributed as an author in a new article on…
Nisha Ponnappan, James Szcz...
Effective delivery of nucleic acids into the cells holds great potential for vaccine development and…
Kerry Shea, Emma Offer, Gay...
This poster describes the use of iPSC derived microglia to develop cell models to…
G.Holliday, D. James, K. Bu...
Medicines Discovery is hard. With high failure rates, often late in the discovery pipeline…
Charles Bury, Matt Hodgskis...
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Kirsty Winn, M. Spisar & Gr...
Normal ageing leads to reduced physical performance and impaired resilience; the rate of onset and…
Chris Southan
MDC engages intensively with patents, a) in various informatics data extraction and integration projects…
Michael Eyres and Gayle Mar...
Traditional analysis of FFPE tissue is often hampered by either low throughput (IHC, IF)…
The aim of this study was to identify an RNA biomarker signature of ageing…
Lauren Toms, Duygu Yilmaz, ...
Super resolution microscopy (Stochastic Optical Reconstruction Microscopy: STORM) enables a resolution of <30nm. This…
Irma Berrueta Razo; Hervé ...
Mass Spectrometry Imaging (MSI) was applied to the analysis of neuroinflammation models. We aim…
Activating mutations in BRAF disrup...
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Structural and Functional View of P...
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Target Identification of Mycobacte...
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The ELF Honest Data Broker: informa...
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A global view of structure–functi...
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Identification of Allosteric Modula...
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Mechanism and Catalytic Site Atlas ...
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Chapter One – Atlas of the Radica...
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Drug Target Commons: A Community Ef...
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Unexplored therapeutic opportunitie...
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Setting Our Sights on Infectious Di...
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Improving the odds of drug developm...
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A global analysis of function and c...
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A strategy for large-scale comparis...
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Artificial intelligence, drug repur...
PCSK9 monoclonal antibodies for the...
Read the full article in the Cochrane…
Barriers to the release of human ti...
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Nucleic acid extraction from formal...
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2′-O-(2-Methoxyethyl) Nucleosides...
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Bubbling up: Introducing a new drug...
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Combined inhibition of PI3Kβ and m...
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Monoclonal antibody targeting of fi...
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The future R&D landscape in non...
Novel methodology to discern predic...
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3D organoid-derived human glomeruli...
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Positioning High-Throughput CETSA i...
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Evaluation of variability in human ...
Generating Kidney from Stem Cells
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Potent, selective, and subunit‐de...
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Optimisation of robust singleplex a...
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High-resolution 3D visualization of...
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Using Collision Cross Section Distr...
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A practical guide to secondary phar...
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Quantification of protein glycation...
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Part 2: SLAS Community Engages in t...
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Coupling Droplet Microfluidics with...
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Translational Roadmap for the Organ...
Coupling 193 nm Ultraviolet Photodi...
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Information-rich high-throughput ce...
On the shuttling across the blood-b...
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A Scalable Approach Reveals Functio...
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