Home » Publications » Structural and Functional View of Polypharmacology
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MDC Chemical Protein Stability Assay (CPSA) a novel target engagement approach Click here for full…
Dr Eve Corrie, Dr Rebecca ...
Dr Eve Corrie, Dr Rebecca Kelly, Dr Matthieu Trigano, and Dr Emma V. Jones
Advanced Microscopy Tools for Drug ...
Matthieu Trigano, Eve Corrie, Rebecca Kelly, Lauren Toms, Nina Vyas, Lorna FitzPatrick, Mairi Challinor, Emma V Jones
Expert-Led Consensus to Sha...
Medicines Discovery Catapult, MND Association and My Name’5 Doddie Foundation have partnered to generate new…
Development of Microscopy Tools to ...
Rebecca Kelly, Sarah Brockbank, Eve Corrie, Lorna Fitzpatrick, Malcolm Haddrick, Emma Jones, Adam Rolt, Martina Sykorova, Nina Vyas and Phillip Auckland
Imaging informatics at Medicines Di...
Nina Vyas, Adam Callan-Sidat, Hervé Barjat
Spatially Resolved Whole Transcript...
Robert Pedley, Michael Eyres, Joesph Bell, Nina Vyas, Herve Barjat1, Donna Davies, Mark Jones, Gayle Marshall, Emily Offer
Identification and Profiling of Bio...
Kerry Shea, Regine Anderson, Michael Eyres, Bruno Bellina, Tara Bowen, Maike Langini, Andrzej Rutkowski, Philippa Hart, Irma Berruta Razo, Lucy Frost, Gayle Marshall
Visualising the biodistribution of ...
Irma Berrueta Razo, Tiffany Allen and Philippa Hart
Nature Feature Article Dece...
Feature article in Nature: Collaboration is reshaping the future of UK drug discovery. Medicines Discovery…
Rebecca Kelly, Eve Corrie, ...
Multimodal Advanced Microscopy to Study Drug Responses in Complex Cell Models More translational models are…
Eve Corrie, Isabel Peset-Ma...
Methods to Examine Neuronal Morphology and Function in Human iPSC-derived Disease Models The ability to…
Eleanor Platt, Lucy Frost, ...
Understanding the Senolytic and Senomorphic Effects of Zoledronate in an Ageing Mouse Model Bisphosphonates (BPs)…
Irma Berrueta Razo, Ping Yi...
Investigation of Lipid Biomarkers in Amyotrophic Lateral Sclerosis Using Mass Spectrometry Imaging The application of…
Emma V. Jones, Lorna M. Fit...
Drug Discovery Tools to Examine Neuroinflammation Signalling in Human iPSC-Derived Microglia Huge challenges exist in…
Michael Eyres, Phillipa Har...
Whole Transcriptome Digital Spatial Profiling of Pain-Induced DRGs Tissues are not homogenous but are made…
Kepa Burusco-Goni, Mouhamad...
A Journey from Protein to Compound: Virtual Screening at MDC: Lately, there has been an…
Aadarash Zia, Nisha Ponnapp...
Efficient Intracellular Delivery of Nucleic Acids by NUVEC® Silica Nanoparticles: In recent years, there has…
Spatially Resolved Deconvolution of...
Read the article at Cell…
Constance Takawira, Paula S...
This poster presents our flagship programme in infectious disease – The Cystic Fibrosis Antimicrobial Resistance…
Gender Pay Gap Report
Medicines Discovery Catapult is committed to equality of opportunity. It has recently formalised its long-held commitment…
Advanced Molecular Imaging for the ...
Our industry experts, Dr Paul Sharp (Senior Scientist) and Dr Martin Main (Head of Discovery)…
Drug Discovery Today
Hearing loss is a serious condition affecting more than 1.5 billion people globally. Many…
IMI European Lead Factory – d...
Our CSO, Prof. Peter Simpson has contributed as an author in a new article on…
Nisha Ponnappan, James Szcz...
Effective delivery of nucleic acids into the cells holds great potential for vaccine development and…
Kerry Shea, Emma Offer, Gay...
This poster describes the use of iPSC derived microglia to develop cell models to…
G.Holliday, D. James, K. Bu...
Medicines Discovery is hard. With high failure rates, often late in the discovery pipeline…
Charles Bury, Matt Hodgskis...
According to the World Health Organisation, the world’s population is ageing faster than ever…
Kirsty Winn, M. Spisar & Gr...
Normal ageing leads to reduced physical performance and impaired resilience; the rate of onset and…
Chris Southan
MDC engages intensively with patents, a) in various informatics data extraction and integration projects…
Michael Eyres and Gayle Mar...
Traditional analysis of FFPE tissue is often hampered by either low throughput (IHC, IF)…
The aim of this study was to identify an RNA biomarker signature of ageing…
Lauren Toms, Duygu Yilmaz, ...
Super resolution microscopy (Stochastic Optical Reconstruction Microscopy: STORM) enables a resolution of <30nm. This…
Irma Berrueta Razo; Hervé ...
Mass Spectrometry Imaging (MSI) was applied to the analysis of neuroinflammation models. We aim…
Activating mutations in BRAF disrup...
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Target Identification of Mycobacte...
Read the article at Frontiers in…
The importance of triaging in deter...
Read the article at Future Medicinal…
The ELF Honest Data Broker: informa...
Read the article at Drug Discovery…
A global view of structure–functi...
Read the article in the Journal of Biological…
Identification of Allosteric Modula...
Read the article at the Journal of Chemical Information and…
Mechanism and Catalytic Site Atlas ...
Read the article in Nucleic Acids…
Chapter One – Atlas of the Radica...
Read the article at Methods in…
Drug Target Commons: A Community Ef...
Read the article at Cell Chemical…
Unexplored therapeutic opportunitie...
Read the article at Nature Reviews Drug…
Setting Our Sights on Infectious Di...
Read the article at ACS Infectious…
Improving the odds of drug developm...
Read the article at Scientific…
A global analysis of function and c...
Read the article at the Journal of Biological…
A strategy for large-scale comparis...
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Artificial intelligence, drug repur...
Strict conformational demands of RN...
Read the full article in Nucleic Acids…
PCSK9 monoclonal antibodies for the...
Read the full article in the Cochrane…
Barriers to the release of human ti...
Read the article at the Journal of Clinical…
Nucleic acid extraction from formal...
Read the article at BMC Clinical…
2′-O-(2-Methoxyethyl) Nucleosides...
Read the paper at Toxological…
Circulating biomarkers and resist...
Read the article at Clinical Cancer…
Bubbling up: Introducing a new drug...
Read the article at European Pharmaceutical…
Combined inhibition of PI3Kβ and m...
Read the article at Molecular Cancer…
Monoclonal antibody targeting of fi...
Read the article at Toxicology and Applied Pharmacology
Rapid translation of novel nephroge...
Read the article at the Australian and New Zealand Society of…
The future R&D landscape in non...
Novel methodology to discern predic...
Read the full article at RMD…
3D organoid-derived human glomeruli...
Read the full article at Nature…
Positioning High-Throughput CETSA i...
Read the full article at Sage…
Evaluation of variability in human ...
Generating Kidney from Stem Cells
Read the full article in the Annual Review of…
Acoustic mist ionization platform f...
Read the full article at Analytical…
Organ-on-a-chip technology: turning...
Read the full article at Drug Discovery…
Potent, selective, and subunit‐de...
Read the full article in the British Journal of…
Optimisation of robust singleplex a...
Read the full article at Nature Scientific…
High-resolution 3D visualization of...
Read the full article at…
Using Collision Cross Section Distr...
Read the full article in Analytical…
A practical guide to secondary phar...
Read the full article in the Journal of Pharmacological and Toxicological…
Quantification of protein glycation...
Read the full article at the Royal Society of Chemistry
What makes a drug discovery consort...
Read the full article in Nature Reviews Drug Discovery
Part 2: SLAS Community Engages in t...
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Coupling Droplet Microfluidics with...
Read the full article in Analytical Chemistry
Investigating sex determination thr...
Read the full article in Forensic…
Ultrasound-triggered therapeutic mi...
Translational Roadmap for the Organ...
Coupling 193 nm Ultraviolet Photodi...
Read the full article in the Journal of the American Society for Mass…
Information-rich high-throughput ce...
On the shuttling across the blood-b...
Read the full article in Science…
A Scalable Approach Reveals Functio...
Read the full article in SLAS…
TET2 drives 5hmc marking of GATA6 a...
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