Use of Microfluidics Technology to Model Pathogenic Protein Seeding in Neurodegeneration in vitro
Microfluidics Technology to Model Pathogenic Protein Seeding in Neurodegeneration in vitro Many neurodegenerative diseases are associated with the presence of misfolded, aggregating proteins within the brain, leading to cytotoxicity and cell death. The prion hypothesis states that these toxic species spread through the brain via anatomically connected regions, leading to widespread neurodegeneration. Examples of prion-like […]
Advanced Microscopy Tools for Drug Discovery: Methods to Examine Cell Morphology and Function in CNS Disease Models
Neurodegenerative disorders remain a global health challenge, requiring sophisticated methodologies for in-depth investigation. Developments in complex in-vitro, iPSC-derived CNS models, together with advanced microscopy tools, will improve our understanding of disease mechanisms facilitating the development of new medicines with better translation to the clinic. Here, we utilise different approaches to examine aspects of cell phenotype […]