Advanced Microscopy Tools for Drug Discovery: Methods to Examine Cell Morphology and Function in CNS Disease Models

Matthieu Trigano, Eve Corrie, Rebecca Kelly, Lauren Toms, Nina Vyas, Lorna FitzPatrick, Mairi Challinor, Emma V Jones

Neurodegenerative disorders remain a global health challenge, requiring sophisticated methodologies for in-depth investigation. Developments in complex in-vitro, iPSC-derived CNS models, together with advanced microscopy tools, will improve our understanding of disease mechanisms facilitating the development of new medicines with better translation to the clinic.

Here, we utilise different approaches to examine aspects of cell phenotype known to be affected in neurodegenerative disorders, using iPSC-derived cells such as neurons and microglia.