Webinar – Complex Medicines: Understanding the Interplay with Biological Systems
The medicines industry is in a period of change. While small molecule therapeutics still make up 90% of approved medicines, patient expectations are driving the industry towards targeted, precision treatments, which require a shift towards stratified, complex medicines with more challenging discovery and development needs. MDC Connects 2021: A Guide to Complex Medicines is a […]
Webinar – Complex Medicines: Selection and Characterisation of the Lead
The medicines industry is in a period of change. While small molecule therapeutics still make up 90% of approved medicines, patient expectations are driving the industry towards targeted, precision treatments, which require a shift towards stratified, complex medicines with more challenging discovery and development needs. MDC Connects 2021: A Guide to Complex Medicines is a […]
Webinar – Complex Medicines: Why? What? When? Opportunities and Challenges
The medicines industry is in a period of change. While small molecule therapeutics still make up 90% of approved medicines, patient expectations are driving the industry towards targeted, precision treatments, which require a shift towards stratified, complex medicines with more challenging discovery and development needs. MDC Connects 2021: A Guide to Complex Medicines is a […]
Webinar – Developing a Biomarker Strategy
Webinar – Developing a Biomarker Strategy from MDC Connects, a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. A common theme throughout our MDC Connects series is that of building confidence in a hypothesis and improving the chances of success in the clinic. […]
Webinar – Is my Compound Safe?
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Safety plays a huge part during preclinical development, and any drug must be extensively tested to regulatory standards before approval to test in humans. Safety-related hazards can arise from target-mediated risk, […]
Webinar – Target Validation and Efficacy
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Project failure due to lack of clinical efficacy during development remains an issue and can in part be attributed to inadequate pre-clinical target validation or clinical translation data. Target validation is […]
Webinar – Understanding the PK / PD Relationship
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Understanding the pharmacokinetic-pharmacodynamic (PK-PD) relationship in preclinical models is crucial to predicting an efficacious dose regime in man. Preclinical PK-PD analysis investigates the dose-response relationship of exposure and biological effect. The […]
Webinar – Chemistry and Formulation
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. The chemistry discipline is instrumental at all stages of drug discovery, from the creation of diverse or targeted libraries for screening, through design, synthesis, formulation and ultimately the scale up and […]
Webinar – Optimising the Compound
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. For a molecule to be worthy of entering preclinical development it needs to have the desired biological activity, as well as DMPK properties and a safety profile appropriate for the targeted […]