× Medicines Discovery Catapult

MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners.

The chemistry discipline is instrumental at all stages of drug discovery, from the creation of diverse or targeted libraries for screening, through design, synthesis, formulation and ultimately the scale up and manufacture of the final drug product.

In this webinar we hear from three chemists. Trevor Perrier from Domainex describes how fragment based drug design can be applied, taking us through a case study which illustrates how low molecular weight fragment hits can be turned into drug candidates. James Hitchin from Charnwood Molecular focusses on synthetic chemistry and the different skills required from early Drug Discovery to Development phases, with particular reference to the way in which transformation maps can be applied to guide decision making. Alison Foster from Quay Pharma describes how the formulation of a compound can be optimised to maximise dose and absorption in preclinical studies and enhance the properties of the API to meet the Target Product Profile in the clinic.


Recording

YouTube video

Slides

IKKe/TBK1: Case study of approaches to turning fragment hits into drug candidates at Domainex

Synthetic chemistry aspects of drug discovery and early development projects at Charnwood Molecular

Designing formulations for early stage pre-clinical and clinical studies’ at Quay Pharma

 

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