Partnering for Impact: The Cystic Fibrosis Antimicrobial Resistance Syndicate
This poster presents our flagship programme in infectious disease – The Cystic Fibrosis Antimicrobial Resistance Syndicate. The Syndicate’s mission is to accelerate the translation and adoption of new CF antimicrobials and diagnostics to the clinic, through collaboration. Bring new treatments to people with CF, faster. View the poster >
Investigation of Nuvec Particles for Effective Gene Delivery
Effective delivery of nucleic acids into the cells holds great potential for vaccine development and cancer treatments. N4 Pharma has been developing Nuvec® – a unique non-viral adjuvant delivery system for the effective delivery of nucleic acids into the cells. This poster details how we carried out biological characterisation of Nuvec particles using a range of methods. This […]
Human iPSC Derived Microglia Cell Assays
This poster describes the use of iPSC derived microglia to develop cell models to functionally characterise a range of phenotypic activities (cytokine release, phagocytotic activity and cell migration) in-vitro. The ability to measure these functions in a lab will allow us to expedite the development of more clinically predictive disease-relevant human cell models for a range […]
From Data to Knowledge: Informatics at MDC
Medicines Discovery is hard. With high failure rates, often late in the discovery pipeline and ever-increasing costs, it is critical that we look for new ways to innovate in this field. Here at Medicines Discovery Catapult, we seek to do just that using a data-driven, patient-centric approach. We have a highly inter-disciplinary and collaborative […]
Drug Repurposing for Elderly And Multimorbid: Dr-EAM.ai
According to the World Health Organisation, the world’s population is ageing faster than ever before with more than 1 billion people aged 60 years or older in 2021. Yet ageing is more than simply getting older, it is a hugely complex process. As part of this collaboration, the cheminformatics team at the MDC, with […]
A roadmap for the discovery of therapeutics in healthy ageing
Normal ageing leads to reduced physical performance and impaired resilience; the rate of onset and progression of which can be mitigated by diet and lifestyle plus underlying genetic inheritance. Lifestyle, environment and genetics then influence acute and chronic changes to the biological processes underlying normal ageing, which can result in morbidity and, over time, the accumulation of additional or […]
40 million open chemical structures from patents: treasure trove? junk yard? or both?
MDC engages intensively with patents, a) in various informatics data extraction and integration projects b) in applications developed from these for our customers and collaborators c) for Competitive Intelligence (CI) landscaping in support of research projects with a bioactive chemistry component. We thus endeavour to keep up with developments in both commercial and open […]
Spatial Proteomics and Transcriptomics using GeoMx Digital Spatial Profiling
Traditional analysis of FFPE tissue is often hampered by either low throughput (IHC, IF) or destruction of spatial information (RNA-seq, nCounter). The NanoString GeoMx Digital Spatial Profiler (DSP) allows for both of these aspects to be maintained by remaining high plex (up to 80-plex proteomics and whole genome transcriptomics) while still maintaining spatial complexity using only […]
Biomarkers of Ageing
The aim of this study was to identify an RNA biomarker signature of ageing within the clinical plasma samples collected from individuals aged below 45 and above 65. This poster was created for ELRIG Drug Discovery 2021 and the Biomarkers UK event. View the poster >