Super resolution microscopy to unravel complex medicine-induced changes in the protein nano environment
Super resolution microscopy (Stochastic Optical Reconstruction Microscopy: STORM) enables a resolution of <30nm. This enhancement allows for visualisation and improved understanding of what is happening at the sub-micrometre level. Here, we are using this technique at the forefront of drug discovery to determine the mechanism of action of a novel complex medicine. The aim is […]
Accumulation of Bioactive Lipids in LPS-Induced Neuroinflammation Models: MSI Biomarkers
Mass Spectrometry Imaging (MSI) was applied to the analysis of neuroinflammation models. We aim to identify active lipid species that accumulate during the inflammation process and the possible ion signatures associated with the presence of activated microglia cells. Multimodal imaging techniques were applied such as MALDI, DESI, TOF-SIMS and microscopy. Created in collaboration with the […]