Translational Imaging
Our portfolio of imaging platforms and infrastructure, coupled with our expertise, gives you access to tools to accelerate your drug development. We focus on non-invasive imaging modalities to study biodistribution, PK and PD, mechanism and efficacy of novel therapeutics. With several technologies to label drugs or cells within the animal, we can work with you to deliver the most appropriate preclinical imaging strategy.
Cellular Sciences
Modelling therapeutic response in disease relevant in vitro assays is the first step to understanding whether a therapeutic engages the appropriate pathways and modulates the relevant functional response.
We establish and apply disease relevant cell models with integrated analysis workflows for disease and therapeutic characterisation. Establishing the link between a candidate lead molecule and its target or its modulation of biological pathways in vitro. Projects involve:
- Cellular target engagement
- Mechanism of action analysis
- Functional and phenotypic assays
- Application of advanced technologies to understand cellular response
Biomarkers
We can identify novel biomarkers to track the impact of your proposed new lead molecule, or test known biomarkers to support the translation of your potential therapeutic. For example, biomarkers to enable patient stratification, demonstrate efficacy or monitor safety endpoints.
Key assay platforms include:
- Spatial biomarker analysis using molecular pathology
- Spatial transcriptomics within tissue sections
- Mass spectrometry imaging
- Bulk analysis of samples using transcriptomics and mass spectrometry
Virtual R&D
We provide an independent service that helps projects mitigate risks, optimise time and resources, and strengthen drug discovery plans. Our experts have experience working in large pharma and biotech SMEs and work in a range of disease and therapy areas. Our project delivery spans programmes developing traditional small molecules, biological medicines such as oligonucleotide and antibody therapeutics, and nanoparticle delivery systems.
Our expertise covers drug discovery from target validation to candidate nomination and beyond. We partner with innovators to provide:
- Drug discovery and disease area advice, insight, critique, and review
- Development of detailed, actionable project plans and target product profiles
- Access to in-house capabilities from our discovery laboratory and informatics teams and through our CRO relationships
A Strategy for Success
Undaunted by complex challenges, we will work in close collaboration with you to define a bespoke project plan. Using our expertise, industry-leading insight and the very best technology, we address your project challenges and create a roadmap for commercial success.
We ask the right questions at the right time. We provide guidance where you may need it, find the right partners to help you, fill gaps in your existing project plan and help manage your project delivery.
Lightening the Load
Drug discovery is high risk, but the rewards are huge. As a National Life Sciences service, we use our unique position and expertise to make every move count for innovators.
We provide the right environment to enable you to de-risk your assets, now and in the future. We develop technologies to boost R&D productivity and stay at the cutting edge of drug discovery. You can also gain access to specialist scientific experts and costly technologies in a flexible manner as you need them.
Finding the Right Partners
Our long-standing network of partners are connected to every part of the Life Sciences sector. We will help you navigate the complex landscape of R&D, understand the skills and expertise that you require, and then connect you with sector-leading partnerships that can help provide the momentum you need to make progress faster.
We help all entrepreneurial scientists at the frontier of changing lives through drug discovery. This includes SME therapeutic developers, technology innovators, large pharma, biotech companies, academics and charities.
