Whether you are investigating mechanisms of disease or validating a drug target, or biomarker, it is critical to have the right tools to extract meaningful biological information.

Our Digital Spatial Profiling (DSP) platform will enable you to quantify and analyse characteristics within whole tissue sections or tissue microarrays to characterise cellular activity within a tissue microenvironment.

We use a state-of-the-art NanoString GeoMX Digital Spatial Profiler platform for spatial tissue analyses in our laboratory.​

There is no need to sacrifice valuable information and use costly samples by trading low-plex spatial analysis for high-plex bulk analysis. We combine the best spatial and molecular profiling technologies.

Digital Spatial Profiling

From a standard tissue section on a microscope slide, we can generate:

• Full transcriptome profiling of discrete regions of interest (ROIs) within tissues
• Profiling data for hundreds of validated proteins from small regions of interest

Enabling you to evaluate the tissue heterogeneity in a rapid and quantitative way with spatial profiling in tissue samples.

We use the best technology available to answer the key translational questions in drug development:

What are the Underlying Drivers of Disease?

• Investigate differences, at a molecular level, within tissue
• Identify novel targets and biomarkers
• Identification of cell types within regions of tissue – linking to single-cell RNAseq data

What is the Impact of Therapy on Disease Biology?

• Demonstrate changes downstream of target engagement in clinical and the pre-clinical model tissue
• Monitor disease response and molecular changes over time
• Identify mechanisms of resistance to standard of care and novel therapies
• Highlight changes with combination options

Who are the Right Patients for Targeted Therapies?

• Generate disease linkage data to help select indications and patient populations
• Generate data to support combination options

Industry-Leading Expertise

Thanks to our DSP capabilities, we can deliver deep insights into:

• Characterisation of complex and heterogeneous tissues to reveal insights that are typically lost in bulk sequencing analysis
• Biomarker identification and molecular characterisation
• Combination of DSP data with single-cell RNA-seq datasets for cellular deconvolution of Regions Of Interest (ROIs)
• Investigation of molecular signalling between ROIs through receptor/ligand interactions

We use a NanoString GeoMX Digital Spatial Profiler platform for spatial tissue analyses in our laboratory. Combining the best spatial and molecular profiling technologies. This enables us to:

• Generate whole-transcriptome spatial analysis and high-plex spatial proteomics data
• Combine high-plex and high-throughput spatial profiling for rapid quantitative assessments
• Offer a flexible solution that conforms to your ever-changing research needs

How it Works

• Protein or RNA probes attached to photocleavable barcodes and hybridised in tissues
• Fluorescent antibodies are added to aid in selecting regions of interest
• ROIs are exposed to UV light, cleaving all barcodes in that regions of interest (ROI)
• Barcodes are extracted using a microcapillary and sequenced
• Quantification and analysis of sequenced barcodes
• Downstream analysis such as differential expression, Single cell deconvolution and receptor/ligand interactions