Multimodal Advanced Microscopy to Study Drug Responses in Complex Cell Models
- More translational models are needed for new medicines. iPSC derived 3D models may provide more benefits than current 2D approaches
- These complex models must be characterised and validated
- We have developed multimodal advanced microscopy approach to combine high-resolution microscopy with complex cell model development
- Using combined high resolution confocal microscopy and high content spinning disk we can determine drug action and deconvolute targets. We can support this with bespoke image analysis workflows for validation and quantification of drug response
- Here we show two models in development at MDC, a CNS triculture model for studying CNS in neuroinflammation and disease, and a CMEF cardiac model, a 3D model for assessing cardiotoxicity
Multimodal Advanced Microscopy to Study Drug Responses in Complex Cell Models
This poster was created for ELRIG Drug Discovery 2022.
