Nucleic Acid Therapeutics – Delivered
Clinical and commercial progress Nucleic acid therapeutics, which address the underlying causes of disease at the gene and RNA levels, have been on the rise in recent years. CRISPR and mRNA therapies have now entered clinical development, with a major therapeutic area focus on oncology and hematology (gene-editing and mRNA therapies), as well as infectious […]
PROTAC Assays – Successfully measuring Protein Degradation
PROTAC (PROteolysis TArgeting Chimera) is one of the hottest topics in drug discovery today as it is a highly promising new approach to targeted therapy. It offers several advantages over traditional occupancy-based drugs, with a potential to target the ‘undruggable’ proteome. Read our blog below to learn more about PROTAC and some assays that can […]
The value of computational chemistry
With the increasing pressure to drive efficiencies in the drug discovery process, innovative approaches using computational chemistry are delivering proven results, particularly in the areas of lead identification and optimisation. However, maintaining an in-house team is often a luxury and there is an increasing trend to outsource computational chemistry in order to benefit from the […]
What is Antiphospholipid Syndrome (APS)?
Antiphospholipid syndrome (APS) is an autoimmune disease in which pathogenic autoantibodies cause development of clots, strokes and/or recurrent miscarriages. APS is the main cause of strokes in people under 50 years old and a major cause of pregnancy loss. Treatment options for APS are very limited. Importantly corticosteroids and immunosuppressive drugs are not effective in […]
Using Electron Microscopy (EM) in drug discovery
Why Electron Microscopy? 88% of the 210 drugs granted FDA approval between 2010 and 2016 were informed by structural biology. Traditionally structural biology has been underpinned by X-ray crystallography and to a lesser extent NMR. However, significant improvements in the field of Electron Microscopy (EM) has provided a powerful approach to studying protein structure. Traditionally […]
Orphan drug review
In the previous article, we established the procedural aspects of EU Orphan Drug Designation. Now let’s look at what elements of orphan disease applications require a more detailed review by COMP (Committee for Orphan Medicinal Products). Prevalence of the disease This definition is quite clear, but it’s important to understand how the terms of classification […]
Orphan drug development
Rare diseases in the European Union Increased awareness of rare diseases and a favourable investment environment for orphan drug development represent opportunities for academic research and SMEs. To convert this potential into patient benefits, research impact and financial revenue it is essential to understand this topic in-depth and navigate pivotal regulatory processes, such as the […]
Techniques in kinase profiling
The role of kinases in human disease is well known in the drug discovery world, making them significant therapeutic intervention points. There are over 500 known kinases in the human kinome and over 150 are mutated or misregulated in various disease states. However, developing a selective kinase inhibitor can be both challenging and time consuming. […]
A guide to sourcing biosamples
Medicines Discovery Catapult and the BioIndustry Association stated in their 2018 State of the Discovery Nation Report, that: “… over 80% of SMEs surveyed agreed that access to biosamples is hugely important for commercial development” and “… as many as 80% found accessing UK samples unexpectedly difficult…” A major recommendation of this report was that […]