Webinar – Target Validation and Efficacy
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Project failure due to lack of clinical efficacy during development remains an issue and can in part be attributed to inadequate pre-clinical target validation or clinical translation data. Target validation is […]
Webinar – Understanding the PK / PD Relationship
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Understanding the pharmacokinetic-pharmacodynamic (PK-PD) relationship in preclinical models is crucial to predicting an efficacious dose regime in man. Preclinical PK-PD analysis investigates the dose-response relationship of exposure and biological effect. The […]
Webinar – Chemistry and Formulation
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. The chemistry discipline is instrumental at all stages of drug discovery, from the creation of diverse or targeted libraries for screening, through design, synthesis, formulation and ultimately the scale up and […]
Webinar – Optimising the Compound
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. For a molecule to be worthy of entering preclinical development it needs to have the desired biological activity, as well as DMPK properties and a safety profile appropriate for the targeted […]
Webinar – Structural Approaches for Drug Discovery
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Structural biology is a vital tool in the drug discovery pipeline. Proteins are the targets for most marketed drugs, and so uncovering the molecular structure of the biological target to high […]
Webinar – Hit Identification
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. The identification of high quality leads is an important step in the discovery of a new drug, but in order to achieve a relevant starting point there are several factors to […]
Webinar – Identifying the Target
MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners. Lack of efficacy is one of the most important causes of failure in clinical trials. Therefore identifying the biological target for a drug discovery project is one of the most important […]