Development of Microscopy Tools to Inform Drug Discovery

Rebecca Kelly, Sarah Brockbank, Eve Corrie, Lorna Fitzpatrick, Malcolm Haddrick, Emma Jones, Adam Rolt, Martina Sykorova, Nina Vyas and Phillip Auckland

Microscopy is a key tool in drug discovery, enabling visualisation of disease phenotypes and therapeutic intervention.

It can be utilised at all stages of the drug discovery process to provide novel biological insights. High content imaging is capable of visualising large numbers of samples at high resolution, becoming a vital approach in industry for evaluating new medicines and disease biology. Here, we present a series of case studies from work at Medicines Discovery Catapult showcasing the impact of high-content imaging on the Opera Phenix spinning disk confocal.