Tissues are not homogenous but are made of multiple discrete compartments. Bulk sequencing methods take a homogenized snapshot, resulting in a huge loss of complexity.
Single-cell sequencing methods allow for the cataloguing of individual components within a tissue. However, it is only with spatial techniques that the relationships between these components can be analysed. GeoMx Digital Spatial Profiling (DSP) enables quantitative, non-destructive, whole transcriptome (WT) profiling in a single FFPE tissue section.