MDC Connects is a series of informative webinars covering the drug discovery process, from our own experts and experts at our CRO network partners.
Structural biology is a vital tool in the drug discovery pipeline. Proteins are the targets for most marketed drugs, and so uncovering the molecular structure of the biological target to high resolution, researchers can directly visualise the interactions of the target with ligands and compounds, information vital to structure-based drug design.
In this webinar we discuss protein production, compare structural approaches and how structural data may be exploited to support chemistry. Derek Ogg from Peak Proteins describes the ins and outs of generating good quality protein suitable for structural studies with particular reference to X-Ray crystallography. Rebecca Thompson from Astbury BioStructure Laboratory shows how the emerging field of CryoEM can be applied to generate structural information for a wide range of targets, and Martin Slater from Cresset Discovery Services describes how structure based and ligand based software tools can be used to virtually discover, design and optimise compounds.
Recording
Slides
Proteins, x-ray crystal structures and how to get them at Peak Proteins
Where can CryoEM be positioned in drug discovery? at Astbury BioStructure Laboratory
Make the molecules that matter at Cresset Discovery Services
