From RNA therapeutics to antibody-drug conjugates, the field of advanced complex medicines is transforming how we treat disease.
These modalities combine active pharmaceutical ingredients with cutting-edge delivery systems to enhance the safety, efficacy and precision of therapeutics.
We have built a flexible, high-resolution platform to support the development, characterisation and translation of complex medicines.
Our platform integrates in vitro, in vivo and ex vivo technologies to guide decision-making and support regulatory preparedness. Using super-resolution microscopy, we can visualise drug-carrier complexes and track their intracellular localisation with precision.
These insights are supported by advanced cell models that evaluate uptake, trafficking, payload release and downstream biological response, providing a detailed understanding of therapeutic behaviour at the cellular level.
To complement in vitro findings, we offer in vivo imaging using PET and optical techniques to monitor biodistribution in real time. Ex vivo tissue analysis, using techniques such as immunofluorescence and label-free Mass Spectrometry imaging, helps map tissue penetration, cell targeting, and molecular activity.
Our molecular pathology expertise allows us to investigate tissue-level drug delivery and biological responses in detail. We also provide support in developing Target Product Profiles (TPPs), offering strategic guidance informed by regulatory, safety and clinical considerations.
Strategic development planning
Build tailored project plans and Target Product Profiles (TPPs) that align with your clinical, regulatory and commercial goals.
Physicochemical and biological characterisation
Evaluate complex medicines for encapsulation, structure, stability, intracellular uptake and trafficking.
Bespoke assay development
Design and deploy bespoke assays using advanced microscopy to assess payload release, target engagement and functional validation in target cell types.
In vivo and ex vivo profiling
Biodistribution studies using advanced preclinical imaging techniques and high-resolution ex vivo tissue analysis to establish cell tropism and efficacy of complex medicines in target tissue.
“To bring novel complex medicines to market, we need new analytical methods to characterise, optimise and develop them. We have built an advanced analytical platform that supports biodistribution, cell targeting and biological response across a wide range of complex modalities.”
Sarah Brockbank, Strategy Leader
Our multi-disciplinary team is ready to help you to build the data, to understand your drug’s properties and improve its performance as a therapeutic.
Fill in the form today and speak to us to see how we can help advance your drug discovery project.